I applied a classical (in the context of Debian) upgrade on my Linux Mint installation and even though Mint is not recommending this option (instead their favorite is a fresh install with restore). Nevertheless my system still works without drawbacks.
In general the Presenter R400 works fine, it’s immediately active after the USB receiver is plugged in and the keys representing Page Up/Down are working out of the box. Thus presentations in LibreOffice/OpenOffice, PDF Viewer (in my case Okular) and Google Docs are stepping forward and backwards using the main keys.
In contrast the smaller keys for jumping to presentation mode and disabling the display are sending codes, that the KDE desktop can’t process.
At least on Linux Mint Petra the mount of an SD card will not survive suspend mode.